Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2507066 | 0.85 | PDE10A (0.53) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2750737 | 0.85 | PDE10A (0.58) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2749825 | 0.84 | PDE10A (0.55) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3506272 | 0.81 | PDE10A (0.51) | PDE10AALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL2500427 | 0.80 | PDE10A (0.49) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2501842 | 0.80 | PDE10A (0.58) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2502039 | 0.80 | PDE10A (0.47) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2496108 | 0.78 | PDE10A (0.47) | PDE10AALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL2504175 | 0.78 | PDE10A (0.52) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14315140 | 0.78 | PDE10A (0.46) | PDE10AALDH1A1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063610-A1 | PYRIDAZINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |