Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 2/20 | 0.64 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.64 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.64 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.64 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.64 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.64 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.64 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.64 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.64 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.64 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721987 | 0.88 | GRIN2D (0.60) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL12043357 | 0.84 | GRIN2D (0.44) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL1722297 | 0.83 | GRIN2D (0.62) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL7913578 | 0.81 | GRIN2D (0.41) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL1721985 | 0.79 | GRIN2D (0.41) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL10187066 | 0.79 | GRIN2D (0.48) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL9037563 | 0.78 | GRIA1 (1.00) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL7907652 | 0.78 | KDM4E (0.62) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL7898667 | 0.77 | GRIN2D (0.55) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 | |
| SCHEMBL7907951 | 0.77 | GRIN2D (0.42) | GRIN2DGRIN3BGRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8674096-B2 | Substituted imidazo[1,5-a]quinoxalin-4-ones as phosphodiesterase 9 inhibitors | ASTELLAS PHARMA INC. (JP) | 2014-03-18 | — | — | US | disclosed |
| US-20130085134-A1 | QUINOXALINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-04-04 | — | — | US | disclosed |
| US-20130085134-A1 | QUINOXALINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-04-04 | — | — | US | disclosed |
| US-8357688-B2 | Substituted imidazo[1,5-a]quinoxalin-4(5H)-ones as PDE9 inhibitors | ASTELLAS PHARMA INC. (JP) | 2013-01-22 | — | — | US | disclosed |
| US-8357688-B2 | Substituted imidazo[1,5-a]quinoxalin-4(5H)-ones as PDE9 inhibitors | ASTELLAS PHARMA INC. (JP) | 2013-01-22 | — | — | US | disclosed |
| EP-2404922-A1 | QUINOXALINE COMPOUNDS | Astellas Pharma Inc. (JP) | 2012-01-11 | — | — | EP | disclosed |
| US-20110319385-A1 | QUINOXALINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-12-29 | — | — | US | disclosed |
| US-20110319385-A1 | QUINOXALINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-12-29 | — | — | US | disclosed |
| WO-2010101230-A1 | QUINOXALINE COMPOUNDS | アステラス製薬株式会社 (JP) | 2010-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130085134-A1 | QUINOXALINE COMPOUND | PDE9A, PDE2A, PDE3A | GRIN2D 4578/4885GRIN3B 4719/4885GRIA1 3726/4885 |
| US-20110319385-A1 | QUINOXALINE COMPOUND | PDE9A, PDE5A, PDE3A | GRIN2D 4810/4885GRIN3B 4848/4885GRIA1 4687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.