Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2509831 | 0.88 | PDE10A (0.69) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2750052 | 0.88 | PDE10A (0.67) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL519406 | 0.86 | CYP1A2 (0.74) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7911489 | 0.85 | PDE10A (0.58) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2476153 | 0.85 | PDE10A (0.65) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14315130 | 0.85 | PDE10A (0.62) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2495991 | 0.84 | PDE10A (0.80) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2497686 | 0.84 | PDE10A (0.74) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2749866 | 0.84 | PDE10A (0.80) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3506408 | 0.84 | PDE10A (0.67) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373641-B1 | PYRIDAZINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-12-19 | — | — | EP | disclosed |
| WO-2010063610-A1 | PYRIDAZINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |