Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | NT5E | P21589 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2545605 | 0.90 | PDE10A (0.70) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2543663 | 0.88 | PDE10A (0.58) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2498366 | 0.88 | PDE10A (0.58) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3504662 | 0.86 | PDE10A (0.63) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2506900 | 0.86 | PDE10A (0.56) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2502159 | 0.86 | PDE10A (0.68) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2505042 | 0.86 | PDE10A (0.57) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7911573 | 0.86 | PDE10A (0.65) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7911442 | 0.86 | PDE10A (0.58) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3503820 | 0.85 | PDE10A (0.61) | PDE10ACYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063610-A1 | PYRIDAZINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-10 | — | — | WO | disclosed |