Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 10/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14385281 | 0.87 | EPHX1 (0.30) | — | |
| SCHEMBL14385370 | 0.80 | TSHR (0.35) | EPHX2TSHRHDAC1HDAC8HDAC6 | |
| SCHEMBL13699365 | 0.78 | GRIN2D (0.33) | — | |
| SCHEMBL7921807 | 0.76 | GRIN2D (0.30) | — | |
| SCHEMBL12858009 | 0.69 | EPHX2 (0.57) | EPHX2TSHRHDAC1HDAC8HDAC6 | |
| SCHEMBL733617 | 0.69 | EPHX2 (0.62) | EPHX2HDAC1HDAC8HDAC6HDAC3 | |
| SCHEMBL16118626 | 0.69 | GAA (0.44) | EPHX2TSHRHDAC1HDAC8HDAC6 | |
| SCHEMBL20082792 | 0.69 | FFAR3 (0.31) | — | |
| SCHEMBL17133526 | 0.68 | TSHR (0.34) | EPHX2TSHRGAA | |
| SCHEMBL4973914 | 0.67 | GAA (0.47) | EPHX2TSHRHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083996-A1 | A PROCESS FOR PREPARING MEMANTINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-07-29 | — | — | WO | disclosed |
| WO-2007132476-A2 | A PROCESS FOR THE PREPARATION OF MEMANTINE HYDROCHLORIDE | MATRIX LABORATORIES LIMITED (IN) | 2007-11-22 | — | — | WO | disclosed |