Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.49 |
| ▸ | MTOR | P42345 | 13/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900395 | 0.82 | PIK3CA (0.72) | PIK3CAMTORFGFR3KDRFLT3 | |
| SCHEMBL379791 | 0.81 | PIK3CA (0.68) | PIK3CAMTOR | |
| SCHEMBL409921 | 0.79 | PIK3CA (0.74) | PIK3CAMTOR | |
| SCHEMBL402628 | 0.79 | PIK3CA (0.46) | PIK3CAMTORFGFR3KDR | |
| SCHEMBL410050 | 0.75 | PIK3CD (0.43) | PIK3CAMTORFGFR3KDRFLT3 | |
| SCHEMBL402271 | 0.65 | PIK3CA (0.74) | PIK3CAMTOR | |
| SCHEMBL22726668 | 0.65 | SIK1 (0.48) | PIK3CAMTOR | |
| SCHEMBL29845383 | 0.65 | KDR (0.50) | FGFR3KDRFLT3 | |
| SCHEMBL23162305 | 0.65 | PIK3CA (0.49) | PIK3CAMTORKDRFLT3 | |
| SCHEMBL380520 | 0.64 | PIK3CA (1.00) | PIK3CAMTORFGFR3KDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010108074-A2 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2010-09-23 | — | — | WO | disclosed |