Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 9/20 | 0.41 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7922608 | 0.93 | IL2 (0.43) | IL2STIM1ORAI1ORAI2NPC1 | |
| Hydrochloric Acid SCHEMBL614560 | 0.92 | IL2 (0.43) | IL2STIM1ORAI1ORAI2NPC1 | |
| SCHEMBL1782159 | 0.91 | IL2 (0.42) | IL2STIM1ORAI1ORAI2NPC1 | |
| SCHEMBL614875 | 0.90 | IL2 (0.43) | IL2STIM1ORAI1ORAI2MALT1 | |
| SCHEMBL7920820 | 0.90 | STIM1 (0.44) | IL2STIM1ORAI1ORAI2MALT1 | |
| Hydrochloric Acid SCHEMBL616904 | 0.89 | STIM1 (0.44) | IL2STIM1ORAI1ORAI2MALT1 | |
| SCHEMBL616586 | 0.87 | TRPV1 (0.41) | IL2STIM1ORAI1ORAI2MALT1 | |
| SCHEMBL10101276 | 0.87 | IL2 (0.40) | IL2STIM1ORAI1ORAI2NPC1 | |
| SCHEMBL10101255 | 0.87 | IL2 (0.44) | IL2STIM1ORAI1ORAI2NPC1 | |
| SCHEMBL616313 | 0.87 | STIM1 (0.43) | IL2STIM1ORAI1ORAI2MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039236-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2010-04-08 | — | — | WO | disclosed |