Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310588 | 0.85 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7915920 | 0.82 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7919822 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL6588339 | 0.81 | CHRM5 (0.42) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7913482 | 0.80 | PDE4B (0.46) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7916316 | 0.79 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7916035 | 0.79 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7916410 | 0.79 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7906247 | 0.77 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7913421 | 0.77 | PDE4B (0.47) | PDE4APDE4BPDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265402-B1 | ANTIINFLAMMATORY AGENTS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-07-24 | — | — | US | disclosed |
| EP-0924204-A1 | 2-PHENYLMORPHOLIN-5-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-06-23 | — | — | EP | disclosed |