Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.45 |
| ▸ | PTPRC | P08575 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTPRF | P10586 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900713 | 0.84 | CYP19A1 (0.66) | CYP19A1CYP11B1CYP11B2NR4A2NR4A1 | |
| SCHEMBL1960673 | 0.79 | NR4A1 (0.72) | CYP19A1CYP11B1CYP11B2PARP10NR4A2 | |
| SCHEMBL26107451 | 0.76 | MAOB (0.71) | PARP10PTPRCPTPN1PTPN2RAB9A | |
| SCHEMBL26106172 | 0.76 | NR4A2 (0.71) | PARP10NR4A2PTPRCPTPN1PTPN2 | |
| SCHEMBL26106274 | 0.76 | NR4A2 (0.71) | PARP10NR4A2PTPRCPTPN1PTPN2 | |
| SCHEMBL3540405 | 0.76 | SMN1; SMN2 (0.71) | PARP10PTPRCPTPN1PTPN2RAB9A | |
| Hydrochloric Acid SCHEMBL14675694 | 0.75 | CYP4F2 (0.49) | PTPRCPTPN1PTPN2RAB9ANPC1 | |
| SCHEMBL7914322 | 0.74 | PARP10 (0.48) | PARP10NR4A2PTPRCPTPN1PTPN2 | |
| SCHEMBL14676030 | 0.73 | NPC1 (0.67) | CYP11B1CYP11B2RAB9ASMN1; SMN2MAPT | |
| SCHEMBL9062623 | 0.73 | PARP10 (0.51) | PARP10NR4A2PTPRCPTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211234-B1 | BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID | RHONE-POULENC RORER LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| EP-0728128-B1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE POULENC RORER LTD (GB) | 1998-09-16 | — | — | EP | disclosed |
| EP-0728128-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013262-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |