Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.50 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | PDE1A | P54750 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598417 | 0.95 | PDE5A (0.72) | PDE5AMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL6594786 | 0.85 | PDE5A (1.00) | PDE5AMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL6594403 | 0.84 | PDE5A (1.00) | PDE5AMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL7911677 | 0.79 | PDE5A (1.00) | PDE5AMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL31038289 | 0.78 | PDE5A (1.00) | PDE5AMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL7495950 | 0.78 | PDE5A (1.00) | PDE5AMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL31034788 | 0.78 | PDE5A (1.00) | PDE5AMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL2458882 | 0.78 | PDE5A (1.00) | PDE5AMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4924574 | 0.78 | PDE5A (0.72) | PDE5AMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL6594377 | 0.77 | PDE4A (0.72) | PDE5AMEN1ALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218392-B1 | FOR THERAPY AND PROPHYLAXIS OF ISCHEMIC HEART DISEASES SUCH AS ANGINA PECTORIS, MYOCARDIAL INFARCT AND CHRONIC AND ACUTE CARDIAC FAILURE, PULMONARY HYPERTENSION, ARTERIOSCLEROSIS AND BRONCHIAL ASTHMA | EISAI CO., LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| US-5849741-A | Fused pyridazine compounds | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0722936-A1 | FUSED PYRIDAZINE COMPOUND | Eisai Co., Ltd. (JP) | 1996-07-24 | — | — | EP | disclosed |