⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16417514 | 1.00 | TRIM24 (0.50) | — | |
| SCHEMBL1566776 | 1.00 | — | — | |
| SCHEMBL1566775 | 1.00 | — | — | |
| SCHEMBL16417516 | 0.97 | TRIM24 (0.47) | — | |
| SCHEMBL16417515 | 0.97 | TRIM24 (0.47) | — | |
| SCHEMBL3394684 | 0.97 | TRIM24 (0.47) | — | |
| SCHEMBL1014667 | 0.97 | TRIM24 (0.47) | — | |
| SCHEMBL3697467 | 0.97 | TRIM24 (0.47) | — | |
| SCHEMBL1014666 | 0.97 | TRIM24 (0.47) | — | |
| SCHEMBL819987 | 0.97 | TRIM24 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262887-A1 | TRANS-CYCLOOCTENES WITH HIGH REACTIVITY AND FAVORABLE PHYSIOCHEMICAL PROPERTIES | University Of Delaware (US) | 2023-10-25 | — | — | EP | claimed |
| WO-2022133225-A1 | TRANS-CYCLOOCTENES WITH HIGH REACTIVITY AND FAVORABLE PHYSIOCHEMICAL PROPERTIES | FOX JOSEPH (US) | 2022-06-23 | — | — | WO | claimed |
| EP-4262887-A1 | TRANS-CYCLOOCTENES WITH HIGH REACTIVITY AND FAVORABLE PHYSIOCHEMICAL PROPERTIES | University Of Delaware (US) | 2023-10-25 | — | — | EP | disclosed |
| US-20230331652-A1 | TRANS-CYCLOOCTENES WITH HIGH REACTIVITY AND FAVORABLE PHYSIOCHEMICAL PROPERTIES | UNIVERSITY OF DELAWARE (US) | 2023-10-19 | — | — | US | disclosed |
| US-20230331652-A1 | TRANS-CYCLOOCTENES WITH HIGH REACTIVITY AND FAVORABLE PHYSIOCHEMICAL PROPERTIES | UNIVERSITY OF DELAWARE (US) | 2023-10-19 | — | — | US | disclosed |
| US-20230144534-A1 | CLEAVABLE TETRAZINE USED IN BIO-ORTHOGONAL DRUG ACTIVATION | TAGWORKS PHARMACEUTICALS B.V. (NL) | 2023-05-11 | — | — | US | disclosed |
| US-11407726-B2 | Using stereoretention for the stereoselective formation of e-macrocycles with Ru-based olefin metathesis catalysts | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2022-08-09 | — | — | US | disclosed |
| WO-2022133225-A1 | TRANS-CYCLOOCTENES WITH HIGH REACTIVITY AND FAVORABLE PHYSIOCHEMICAL PROPERTIES | FOX JOSEPH (US) | 2022-06-23 | — | — | WO | disclosed |
| US-20200385360-A1 | USING STEREORETENTION FOR THE STEREOSELECTIVE FORMATION OF E-MACROCYCLES WITH RU-BASED OLEFIN METATHESIS CATALYSTS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2020-12-10 | — | — | US | disclosed |
| WO-2010056320-A2 | PI3K/MTOR KINASE INHIBITORS | TYROGENEX, INC. (US) | 2010-05-20 | — | — | WO | disclosed |
| US-7645781-B2 | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives | PFIZER INC (US) | 2010-01-12 | — | — | US | disclosed |