Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.42 |
| ▸ | PRKCH | P24723 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1310382 | 0.91 | PIK3CA (0.54) | PIK3CAPIK3CGPIK3CDROCK2ROCK1 | |
| SCHEMBL1309310 | 0.88 | PIK3CA (0.56) | PIK3CAPIK3CGPIK3CDDAPK3RPS6KA3 | |
| SCHEMBL1309797 | 0.84 | PIK3CA (0.64) | PIK3CAPIK3CGPIK3CDROCK2DAPK3 | |
| SCHEMBL1309232 | 0.80 | PIK3CA (0.49) | PIK3CAPIK3CGPIK3CDCYP2C9PARP1 | |
| SCHEMBL1308625 | 0.79 | PIK3CA (0.50) | PIK3CAPIK3CGPIK3CDMTORPIK3CB | |
| SCHEMBL1309744 | 0.77 | PIK3CD (0.55) | PIK3CAPIK3CGPIK3CDCYP2C9DAPK3 | |
| SCHEMBL1309577 | 0.77 | PIK3CA (0.60) | PIK3CAPIK3CGPIK3CDROCK2ROCK1 | |
| SCHEMBL1311475 | 0.75 | PIK3CA (0.49) | PIK3CAPIK3CGPIK3CDROCK2DAPK3 | |
| SCHEMBL1311947 | 0.74 | PIK3CA (0.73) | PIK3CAPIK3CGPIK3CDDAPK3RPS6KA3 | |
| SCHEMBL190060 | 0.74 | PIK3CA (0.73) | PIK3CAPIK3CGPIK3CDDAPK3RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052569-A2 | TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2010-05-14 | — | — | WO | disclosed |