Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.64 |
| ▸ | MTOR | P42345 | 14/20 | 0.64 |
| ▸ | RICTOR | Q6R327 | 5/20 | 0.64 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.64 |
| ▸ | MAPKAP1 | Q9BPZ7 | 5/20 | 0.64 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.51 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17748757 | 0.87 | PIK3CA (0.75) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL17748743 | 0.83 | PIK3CA (0.76) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL1309334 | 0.82 | PIK3CA (0.62) | PIK3CAMTORPIK3CBMAP3K12PIK3R1 | |
| SCHEMBL30356541 | 0.81 | PIK3CA (0.61) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL1311948 | 0.81 | PIK3CA (0.71) | PIK3CAMTORPIK3CBPIK3R1AKT1 | |
| SCHEMBL17748735 | 0.78 | MTOR (1.00) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL17748646 | 0.78 | PIK3CA (0.68) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL1310293 | 0.78 | PIK3CA (0.68) | PIK3CAMTORPIK3CBMAP3K12PIK3R1 | |
| SCHEMBL29880060 | 0.76 | MTOR (0.71) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL17748693 | 0.76 | MTOR (0.71) | PIK3CAMTORRICTORRPTORMAPKAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052569-A2 | TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2010-05-14 | — | — | WO | disclosed |