Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 14/20 | 0.71 |
| ▸ | HTR2A | P28223 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | THPO | P40225 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DRD5 | P21918 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8184939 | 0.87 | DRD1 (0.70) | DRD1HTR2AHSD17B10THPOMAPK1 | |
| SCHEMBL16508939 | 0.84 | DRD1 (0.76) | DRD1HTR2AHSD17B10THPOMAPK1 | |
| SCHEMBL9838068 | 0.83 | DRD1 (1.00) | DRD1HTR2AHSD17B10THPOMAPK1 | |
| SCHEMBL8085146 | 0.83 | DRD1 (1.00) | DRD1HTR2AHSD17B10THPOMAPK1 | |
| SCHEMBL11639646 | 0.80 | SLC6A4 (0.67) | DRD1DRD2CYP2D6 | |
| SCHEMBL7919454 | 0.80 | DRD1 (0.70) | DRD1HTR2AHSD17B10THPOMAPK1 | |
| SCHEMBL7919553 | 0.80 | DRD1 (0.66) | DRD1HTR2AHSD17B10THPOMAPK1 | |
| SCHEMBL7922422 | 0.75 | DRD1 (0.70) | DRD1HTR2AHSD17B10THPOMAPK1 | |
| SCHEMBL7919382 | 0.73 | DRD1 (0.72) | DRD1HTR2AHSD17B10THPOMAPK1 | |
| SCHEMBL14533569 | 0.73 | DRD1 (0.80) | DRD1HTR2AHSD17B10THPOMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211173-B1 | Use of 2,3,4,5-tetrahydro-1H-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders | CENES LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |