Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.75 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.57 |
| ▸ | CTSD | P07339 | 6/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013419 | 0.96 | BACE1 (0.80) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL15510293 | 0.86 | BACE1 (0.74) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL2013214 | 0.86 | BACE1 (1.00) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL15510394 | 0.86 | BACE1 (1.00) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL2013220 | 0.86 | BACE1 (1.00) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL15509792 | 0.85 | BACE1 (0.79) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL15510628 | 0.84 | BACE1 (0.65) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL15509733 | 0.84 | BACE1 (0.82) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL2013513 | 0.83 | BACE1 (0.66) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL1998606 | 0.83 | BACE1 (0.80) | BACE1KCNH2BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010030954-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-03-18 | — | — | WO | disclosed |