Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.60 |
| ▸ | MTOR | P42345 | 17/20 | 0.60 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.60 |
| ▸ | RICTOR | Q6R327 | 7/20 | 0.60 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.60 |
| ▸ | MAPKAP1 | Q9BPZ7 | 7/20 | 0.60 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.60 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.60 |
| ▸ | PRKDC | P78527 | 1/20 | 0.60 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.60 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1309705 | 0.96 | PIK3CA (0.65) | PIK3CAMTORPIK3R1RICTORRPTOR | |
| SCHEMBL23505771 | 0.81 | PIK3CA (0.91) | PIK3CAMTORPIK3R1RICTORRPTOR | |
| SCHEMBL1309020 | 0.79 | PIK3CA (0.64) | PIK3CAMTORPIK3R1RICTORRPTOR | |
| SCHEMBL1310017 | 0.78 | PIK3CA (0.64) | PIK3CAMTORPIK3R1RICTORRPTOR | |
| SCHEMBL18117895 | 0.77 | PIK3CA (0.91) | PIK3CAMTORPIK3R1RICTORRPTOR | |
| SCHEMBL855515 | 0.76 | PIK3CA (1.00) | PIK3CAMTORPIK3R1RICTORRPTOR | |
| Bimiralisib SCHEMBL29352266 | 0.76 | PIK3CA (1.00) | PIK3CAMTORPIK3R1RICTORRPTOR | |
| Bimiralisib SCHEMBL1309049 | 0.76 | PIK3CA (1.00) | PIK3CAMTORPIK3R1RICTORRPTOR | |
| SCHEMBL1310542 | 0.76 | PIK3CA (0.61) | PIK3CAMTORPIK3R1RICTORRPTOR | |
| SCHEMBL1309899 | 0.75 | PIK3CA (0.55) | PIK3CAMTORPIK3R1RICTORRPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052569-A2 | TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2010-05-14 | — | — | WO | disclosed |