Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1966704 | 0.83 | CXCR2 (0.41) | IRAK4MEN1TTRALBKMT2A | |
| SCHEMBL8250121 | 0.79 | KDM4E (0.53) | IRAK4JAK2JAK1TYK2JAK3 | |
| SCHEMBL20355373 | 0.78 | IRAK4 (0.42) | IRAK4JAK2JAK1TYK2JAK3 | |
| SCHEMBL12391599 | 0.77 | HPGD (0.44) | MEN1KMT2ACXCR2CXCR1JAK2 | |
| SCHEMBL2778741 | 0.76 | PTGES2 (0.46) | IRAK4GPR6 | |
| SCHEMBL432239 | 0.76 | IRAK4 (0.44) | IRAK4EGLN2 | |
| SCHEMBL29525774 | 0.76 | IRAK4 (0.44) | IRAK4EGLN2 | |
| SCHEMBL13135634 | 0.74 | CXCR2 (0.42) | MEN1TTRALBKMT2ACXCR2 | |
| SCHEMBL1117928 | 0.74 | KDM4E (0.42) | MEN1TTRALBKMT2ACXCR2 | |
| SCHEMBL29673232 | 0.73 | KDM4E (0.51) | IRAK4MEN1KMT2APIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228868-B1 | ANTICARCINOGENIC AND ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-08 | — | — | US | disclosed |
| WO-2000006556-A1 | SUBSTITUTED OXAZOLINES AS ANTIPROLIFERATIVE AGENTS | ABBOTT LABORATORIES (US) | 2000-02-10 | — | — | WO | disclosed |