Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 7/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 10/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8574891 | 0.99 | BRS3 (0.56) | BRS3CYP11B1CYP11B2CYP3A4HPGDS | |
| SCHEMBL7919393 | 0.89 | BRS3 (0.62) | BRS3CYP11B1CYP11B2HPGDSHRH3 | |
| Hydrochloric Acid SCHEMBL8521500 | 0.88 | BRS3 (0.61) | BRS3CYP11B1CYP11B2HPGDSHRH3 | |
| SCHEMBL7912541 | 0.87 | BRS3 (0.51) | BRS3CYP11B1HRH3 | |
| SCHEMBL7919761 | 0.86 | BRS3 (0.57) | BRS3CYP11B1HRH3 | |
| SCHEMBL8309107 | 0.82 | BRS3 (0.46) | BRS3CYP11B1CYP11B2HPGDSHRH3 | |
| SCHEMBL8309756 | 0.82 | BRS3 (0.53) | BRS3CYP11B1CYP11B2HRH3CYP19A1 | |
| SCHEMBL7453578 | 0.82 | BRS3 (0.43) | BRS3 | |
| SCHEMBL8107106 | 0.82 | BRS3 (0.51) | BRS3CYP11B1CYP11B2HRH3 | |
| SCHEMBL7924356 | 0.81 | BRS3 (0.72) | BRS3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2001524079-A | — | — | 2001-11-27 | — | — | JP | claimed |
| EP-0973396-A4 | A METHOD OF TREATING CANCER | MERCK & CO INC (US) | 2001-02-07 | — | — | EP | claimed |
| EP-0973396-A1 | A METHOD OF TREATING CANCER | Merck & Co., Inc. (US) | 2000-01-26 | — | — | EP | claimed |
| EP-0891361-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1998044797-A1 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 1998-10-15 | — | — | WO | claimed |
| WO-1997036901-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | claimed |
| EP-0891361-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036901-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |