Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 17/20 | 0.68 |
| ▸ | JAK2 | O60674 | 4/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11899410 | 0.84 | TYK2 (0.78) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL792152 | 0.83 | TYK2 (0.77) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL791952 | 0.83 | TYK2 (0.73) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL807673 | 0.82 | TYK2 (0.72) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL792148 | 0.81 | TYK2 (0.76) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL797274 | 0.81 | TYK2 (0.82) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL792044 | 0.81 | TYK2 (1.00) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL793102 | 0.80 | TYK2 (0.43) | TYK2JAK2 | |
| SCHEMBL792996 | 0.80 | TYK2 (0.74) | TYK2JAK2JAK1CDK2CDK9 | |
| SCHEMBL792340 | 0.79 | TYK2 (0.73) | TYK2JAK2JAK1CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8697708-B2 | Azabenzothiazole compounds, compositions and methods of use | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-15 | — | — | US | claimed |
| US-8697708-B2 | Azabenzothiazole compounds, compositions and methods of use | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-15 | — | — | US | disclosed |
| EP-2616072-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035039-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-22 | — | — | WO | disclosed |