Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 6/20 | 0.46 |
| ▸ | HTR1B | P28222 | 6/20 | 0.46 |
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7921703 | 0.83 | HTR1D (0.46) | HTR1DHTR1BHTR2AALDH1A1KDM4E | |
| Oxalic Acid SCHEMBL6924935 | 0.76 | HTR1D (0.74) | HTR1DHTR1BHTR2AALDH1A1KDM4E | |
| Oxalic Acid SCHEMBL6928211 | 0.69 | HTR1D (0.71) | HTR1DHTR1BHTR2AALDH1A1KDM4E | |
| SCHEMBL7448433 | 0.67 | HTR1D (0.54) | HTR1DHTR1BHTR2AALDH1A1KDM4E | |
| SCHEMBL7920439 | 0.67 | MCHR1 (0.46) | HTR1DHTR1BHTR2AALDH1A1KDM4E | |
| SCHEMBL7920434 | 0.65 | MCHR1 (0.45) | HTR1DHTR1BHTR2AALDH1A1KDM4E | |
| Oxalic Acid SCHEMBL6924129 | 0.64 | HTR1D (0.86) | HTR1DHTR1BHTR2AALDH1A1KDM4E | |
| SCHEMBL7921711 | 0.64 | EHMT2 (0.39) | HTR1DHTR1BHTR2AMEN1KMT2A | |
| SCHEMBL6928454 | 0.63 | HTR1D (1.00) | HTR1DHTR1BHTR2AALDH1A1KDM4E | |
| SCHEMBL5432776 | 0.62 | HTR1D (0.91) | HTR1DHTR1BHTR2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001766-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2001-04-04 | — | — | EP | disclosed |
| EP-1001766-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999001127-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-14 | — | — | WO | disclosed |