Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 17/20 | 0.83 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.83 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.83 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.83 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.83 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.83 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.83 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.83 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.83 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.83 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.83 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.83 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.83 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.83 |
| ▸ | CTSB | P07858 | 1/20 | 0.83 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.83 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.83 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.83 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8267939 | 1.00 | PSMB5 (0.83) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL12938153 | 1.00 | PSMB5 (0.83) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL8271184 | 0.96 | PSMB5 (0.76) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL8448141 | 0.92 | PSMB5 (0.71) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL12952611 | 0.92 | PSMB5 (0.69) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL8081495 | 0.92 | PSMB5 (0.69) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL17309078 | 0.92 | PSMB5 (0.90) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| Carfilzomib SCHEMBL23616374 | 0.91 | PSMB5 (1.00) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| Carfilzomib SCHEMBL20825320 | 0.91 | PSMB5 (1.00) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| Carfilzomib SCHEMBL20825324 | 0.91 | PSMB5 (1.00) | PSMB5PSMB9PSMB8PSMB10PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048298-A1 | COMBINATION THERAPY WITH PEPTIDE EPOXYKETONES | PROTEOLIX, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2006063154-A1 | COMPOSITION FOR PROTEASOME INHIBITION | PROTEOLIX, INC. (US) | 2006-06-15 | — | — | WO | disclosed |