Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.69 |
| ▸ | CTSD | P07339 | 5/20 | 0.64 |
| ▸ | CTSE | P14091 | 1/20 | 0.64 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12235455 | 0.91 | BACE1 (0.71) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL6845279 | 0.90 | BACE1 (0.74) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL13401352 | 0.90 | BACE1 (0.74) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL12236607 | 0.87 | BACE1 (0.69) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL15509604 | 0.85 | BACE1 (0.70) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL2006851 | 0.85 | BACE1 (0.83) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL2006847 | 0.85 | BACE1 (0.83) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL1995731 | 0.85 | BACE1 (0.68) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL1995727 | 0.85 | BACE1 (0.68) | BACE1KCNH2CTSDCTSEBACE2 | |
| SCHEMBL15509890 | 0.84 | BACE1 (0.82) | BACE1KCNH2CTSDCTSEBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100087429-A1 | SPIRO-TRICYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-04-08 | — | — | US | disclosed |
| WO-2010030954-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087429-A1 | SPIRO-TRICYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | BACE1, BACE2, APP | BACE1 1/4885KCNH2 3343/4885CTSD 747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.