Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.59 |
| ▸ | TRPA1 | O75762 | 8/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.42 |
| ▸ | METAP2 | P50579 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 3/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20132550 | 0.84 | AXL (0.43) | AXLTRPA1TRPV1CDK2FLT3 | |
| SCHEMBL24175930 | 0.81 | AXL (0.54) | AXLTRPA1TRPM8TRPV1METAP2 | |
| SCHEMBL22967876 | 0.79 | AXL (0.56) | AXLTRPA1TRPM8TRPV1CDK2 | |
| SCHEMBL29383280 | 0.79 | AXL (0.59) | AXLTRPA1TRPM8TRPV1CDK2 | |
| SCHEMBL19617855 | 0.79 | AXL (0.59) | AXLTRPA1TRPM8TRPV1CDK2 | |
| SCHEMBL26713980 | 0.78 | AXL (0.54) | AXLTRPA1TRPM8TRPV1CDK2 | |
| SCHEMBL26714988 | 0.77 | AXL (0.49) | AXLTRPA1TRPM8TRPV1CDK2 | |
| SCHEMBL7918824 | 0.76 | IDO1 (0.43) | AXLTRPA1CDK2FLT3CCNA1 | |
| SCHEMBL18456308 | 0.75 | AXL (0.50) | AXLTRPA1TRPM8TRPV1CDK2 | |
| SCHEMBL8404436 | 0.75 | IDO1 (0.46) | AXLTRPA1CDK2FLT3CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022002102-A1 | QUINAZOLINE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | InventisBio Co., Ltd. (CN) | 2022-01-06 | — | — | WO | disclosed |
| WO-2021063346-A1 | KRAS G12C INHIBITOR AND APPLICATION THEREOF | 上海迪诺医药科技有限公司 | 2021-04-08 | — | — | WO | disclosed |
| WO-2021057832-A1 | KRAS MUTANT PROTEIN INHIBITOR | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2021-04-01 | — | — | WO | disclosed |
| US-8921361-B2 | Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes | UNIVERSITY OF BASEL (CH) | 2014-12-30 | — | — | US | disclosed |
| WO-2010052569-A2 | TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2010-05-14 | — | — | WO | disclosed |