Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.68 |
| ▸ | MEN1 | O00255 | 8/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | MITF | O75030 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9134339 | 0.89 | KMT2A (0.83) | KMT2AMEN1RAB9ANPC1MITF | |
| SCHEMBL23898948 | 0.89 | KMT2A (0.83) | KMT2AMEN1RAB9ANPC1MITF | |
| SCHEMBL8572381 | 0.89 | KMT2A (0.83) | KMT2AMEN1RAB9ANPC1MITF | |
| SCHEMBL16367722 | 0.84 | KMT2A (0.76) | KMT2AMEN1RAB9ANPC1MITF | |
| SCHEMBL24213121 | 0.84 | KMT2A (0.76) | KMT2AMEN1RAB9ANPC1MITF | |
| SCHEMBL674700 | 0.83 | KMT2A (0.73) | KMT2AMEN1RAB9ANPC1MITF | |
| SCHEMBL7881346 | 0.83 | KMT2A (0.79) | KMT2AMEN1RAB9ANPC1MITF | |
| SCHEMBL9137224 | 0.83 | KMT2A (0.73) | KMT2AMEN1RAB9ANPC1MITF | |
| SCHEMBL8442764 | 0.83 | KMT2A (0.73) | KMT2AMEN1RAB9ANPC1MITF | |
| SCHEMBL7696438 | 0.83 | KMT2A (0.79) | KMT2AMEN1RAB9ANPC1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019419-A4 | PHOSPHONATED AGENTS AND THEIR ANTIANGIOGENIC AND ANTITUMORIGENIC USE | UNIV KENTUCKY RES FOUND (US) | 2001-12-12 | — | — | EP | disclosed |
| US-6160166-A | Phosphonated agents and their antiangiogenic and antitumorigenic use | THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2000-12-12 | — | — | US | disclosed |
| US-6096730-A | Phosphonated agents and their antiangiogenic and antitumorigenic use | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2000-08-01 | — | — | US | disclosed |
| EP-1019419-A1 | PHOSPHONATED AGENTS AND THEIR ANTIANGIOGENIC AND ANTITUMORIGENIC USE | The University of Kentucky Research Foundation (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999005148-A1 | PHOSPHONATED AGENTS AND THEIR ANTIANGIOGENIC AND ANTITUMORIGENIC USE | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 1999-02-04 | — | — | WO | disclosed |