Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 1.00 |
| ▸ | BACE2 | Q9Y5Z0 | 15/20 | 1.00 |
| ▸ | CTSD | P07339 | 10/20 | 0.74 |
| ▸ | REN | P00797 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7921788 | 1.00 | BACE1 (1.00) | BACE1BACE2CTSDREN | |
| SCHEMBL4971919 | 1.00 | BACE1 (1.00) | BACE1BACE2CTSDREN | |
| SCHEMBL4961484 | 0.91 | BACE1 (0.83) | BACE1BACE2CTSDREN | |
| SCHEMBL4965239 | 0.90 | BACE1 (1.00) | BACE1BACE2CTSDREN | |
| SCHEMBL4306099 | 0.90 | BACE1 (1.00) | BACE1BACE2CTSDREN | |
| SCHEMBL7923397 | 0.90 | BACE1 (1.00) | BACE1BACE2CTSDREN | |
| SCHEMBL4318188 | 0.86 | BACE1 (1.00) | BACE1BACE2CTSDREN | |
| SCHEMBL4240351 | 0.86 | BACE1 (0.81) | BACE1BACE2CTSD | |
| SCHEMBL20625060 | 0.85 | BACE1 (0.74) | BACE1BACE2CTSDREN | |
| SCHEMBL4318679 | 0.84 | BACE1 (0.73) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042908-A1 | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR BETA-SECRETASE MODULATION | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-20090042908-A1 | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR BETA-SECRETASE MODULATION | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-7452885-B2 | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation | WYETH (US) | 2008-11-18 | — | — | US | disclosed |
| WO-2007005404-A1 | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION | WYETH (US) | 2007-01-11 | — | — | WO | disclosed |
| US-20070004730-A1 | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation | WYETH (US) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004730-A1 | Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation | BACE1, BACE2, APP | BACE1 1/4885BACE2 2/4885CTSD 145/4885 |
| US-20090042908-A1 | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR BETA-SECRETASE MODULATION | BACE1, BACE2, APP | BACE1 1/4885BACE2 2/4885CTSD 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.