Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 12/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.58 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.58 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | ESRRB | O95718 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.58 |
| ▸ | SHBG | P04278 | 1/20 | 0.58 |
| ▸ | PGR | P06401 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7923894 | 1.00 | ESR1 (0.61) | ESR1ESR2HSD17B10LMNATSHR | |
| SCHEMBL8775817 | 0.85 | ESR1 (0.58) | ESR1ESR2HSD17B10LMNATSHR | |
| SCHEMBL29198797 | 0.83 | ESR1 (0.69) | ESR1ESR2HSD17B10LMNATSHR | |
| SCHEMBL4906263 | 0.83 | ESR1 (0.69) | ESR1ESR2HSD17B10LMNATSHR | |
| SCHEMBL18919494 | 0.83 | ESR1 (0.69) | ESR1ESR2HSD17B10LMNATSHR | |
| SCHEMBL4903481 | 0.83 | ESR1 (0.69) | ESR1ESR2HSD17B10LMNATSHR | |
| SCHEMBL4903486 | 0.83 | ESR1 (0.69) | ESR1ESR2HSD17B10LMNATSHR | |
| SCHEMBL18935788 | 0.83 | ESR1 (0.69) | ESR1ESR2HSD17B10LMNATSHR | |
| SCHEMBL22368047 | 0.83 | ESR1 (0.69) | ESR1ESR2HSD17B10LMNATSHR | |
| SCHEMBL30060206 | 0.83 | ESR1 (0.69) | ESR1ESR2HSD17B10LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686037-B1 | HORMONE REPLACEMENT THERAPY | HAMPTON ROADS MEDICAL COLLEGE (US) | 2001-06-20 | — | — | EP | disclosed |