Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | PNMT | P11086 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3302850 | 1.00 | BACE1 (0.33) | BACE1BACE2ADRA2APNMT | |
| SCHEMBL17794294 | 0.84 | BACE1 (0.44) | BACE1BACE2 | |
| SCHEMBL15768978 | 0.82 | BACE1 (0.40) | BACE1BACE2 | |
| SCHEMBL6877967 | 0.79 | BACE1 (0.35) | BACE1BACE2 | |
| SCHEMBL932759 | 0.79 | BACE1 (0.35) | BACE1BACE2 | |
| SCHEMBL18195491 | 0.79 | BACE1 (0.35) | BACE1BACE2 | |
| SCHEMBL20271923 | 0.79 | BACE1 (0.33) | BACE1BACE2ADRA2APNMT | |
| SCHEMBL20271915 | 0.79 | BACE1 (0.33) | BACE1BACE2ADRA2APNMT | |
| SCHEMBL18087449 | 0.76 | BACE1 (0.37) | BACE1BACE2 | |
| SCHEMBL18076280 | 0.76 | BACE1 (0.37) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038686-A1 | NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE | エーザイ・アール・アンド・ディー・マネジメント株式会社 (JP) | 2010-04-08 | — | — | WO | disclosed |