Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | THRB | P10828 | 1/20 | 0.75 |
| ▸ | RECQL | P46063 | 1/20 | 0.75 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.75 |
| ▸ | RARB | P10826 | 9/20 | 0.60 |
| ▸ | RARG | P13631 | 8/20 | 0.60 |
| ▸ | RARA | P10276 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7932561 | 0.88 | MEN1 (0.64) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL29462721 | 0.87 | RARB (0.74) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL3677626 | 0.87 | RARB (0.74) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL173380 | 0.86 | MEN1 (1.00) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL29359220 | 0.86 | MEN1 (1.00) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL7929574 | 0.85 | MEN1 (0.54) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL7929455 | 0.85 | MEN1 (0.54) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL7929457 | 0.84 | RARB (0.56) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL7929994 | 0.83 | MEN1 (0.67) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL7932584 | 0.82 | RARB (0.53) | MEN1KMT2ATHRBRECQLNR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225328-B1 | FOR THERAPY OF DISORDERS OR AILMENTS RELATED TO AN OVERREGULATION OF RETINOIC ACID RECEPTORS AND/OR TO HYPERVIAMINOSIS A | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2001-05-01 | — | — | US | disclosed |
| US-5952382-A | INHIBITING THE BIOLOGICAL EFFECTS OF AN OVERREGULATION OF RETINOID ACID RECEPTORS AND/OR OF A HYPERVITAMINOSIS A; TREATING SKIN DISORDER, EYE VISION DEFECTS, SKIN AGING | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-09-14 | — | — | US | disclosed |
| US-5723499-A | Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | C.I.R.D. GALDERMA (FR) | 1998-03-03 | — | — | US | disclosed |