Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 19/20 | 0.58 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL508469 | 0.91 | PDE4D (0.63) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7919033 | 0.85 | PDE4D (0.55) | PDE4DPDE4A | |
| SCHEMBL3469123 | 0.85 | PDE4D (0.65) | PDE4DPDE4A | |
| SCHEMBL7924211 | 0.83 | PDE4D (0.59) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL17554735 | 0.82 | PDE4D (0.68) | PDE4D | |
| SCHEMBL17554738 | 0.82 | PDE4D (0.71) | PDE4D | |
| SCHEMBL508470 | 0.81 | PDE4D (0.64) | PDE4DPDE4A | |
| SCHEMBL510097 | 0.80 | PDE4D (0.60) | PDE4DPDE4A | |
| SCHEMBL509333 | 0.79 | PDE4D (0.62) | PDE4DPDE4A | |
| SCHEMBL508750 | 0.78 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379548-B1 | TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF DERMAL DISEASES | LEO PHARMA AS (DK) | 2016-03-09 | — | — | EP | disclosed |
| WO-2010069322-A1 | TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF DERMAL DISEASES | LEO PHARMA A/S (DK) | 2010-06-24 | — | — | WO | disclosed |