Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7931152 | 0.94 | HPGD (0.55) | HPGDMAPTHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL13010769 | 0.90 | HPGD (0.55) | HPGDMAPTHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL21823421 | 0.90 | HPGD (0.55) | HPGDMAPTHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL16362200 | 0.90 | SMN1; SMN2 (0.52) | HPGDMAPTHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL1459228 | 0.88 | SMN1; SMN2 (0.54) | HPGDMAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL5441890 | 0.86 | SMN1; SMN2 (0.52) | HPGDSMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL29840690 | 0.86 | SMN1; SMN2 (0.52) | HPGDSMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL1777203 | 0.86 | SMN1; SMN2 (0.52) | HPGDSMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL26667665 | 0.86 | HPGD (0.54) | HPGDMAPTHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL21823752 | 0.84 | HPGD (0.54) | HPGDMAPTHSD17B10KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140896-A1 | BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 | Takeda Chemical Industries, Ltd. (JP) | 2001-10-10 | — | — | EP | disclosed |
| US-6235771-B1 | AIDS THERPAY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| WO-2000037455-A1 | BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-06-29 | — | — | WO | disclosed |