Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 16/20 | 0.56 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL793903 | 0.84 | TYK2 (0.60) | TYK2JAK2SCN9ALCK | |
| SCHEMBL792816 | 0.84 | TYK2 (0.63) | TYK2JAK2SCN9A | |
| Hydrochloric Acid SCHEMBL793628 | 0.83 | TYK2 (0.62) | TYK2JAK2SCN9A | |
| SCHEMBL807375 | 0.82 | TYK2 (0.67) | TYK2JAK2 | |
| Formic Acid SCHEMBL793902 | 0.81 | TYK2 (0.74) | TYK2JAK2LCK | |
| SCHEMBL793027 | 0.80 | TYK2 (0.67) | TYK2JAK2SCN9A | |
| SCHEMBL11898927 | 0.79 | TYK2 (0.59) | TYK2JAK2 | |
| Hydrochloric Acid SCHEMBL793360 | 0.79 | TYK2 (0.66) | TYK2JAK2SCN9A | |
| SCHEMBL807526 | 0.79 | TYK2 (0.80) | TYK2JAK2LCK | |
| SCHEMBL11960363 | 0.76 | TYK2 (0.66) | TYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616072-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035039-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-22 | — | — | WO | disclosed |