Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 4/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | HTR5A | P47898 | 1/20 | 0.30 |
| ▸ | PRCP | P42785 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2024487 | 0.73 | MAPT (0.43) | GAAMAPTARBRD4CREBBP | |
| SCHEMBL30059612 | 0.68 | MAPT (0.53) | GAAMAPTARBRD4CREBBP | |
| SCHEMBL22341668 | 0.67 | GAA (0.48) | GAAMAPTARBRD4CREBBP | |
| SCHEMBL4978935 | 0.66 | PRCP (0.55) | GAAMAPTARBRD4KDM4E | |
| SCHEMBL29779937 | 0.66 | PRCP (0.55) | GAAMAPTARBRD4KDM4E | |
| SCHEMBL18068338 | 0.66 | GAA (0.40) | GAAMAPTARBRD4CREBBP | |
| SCHEMBL1736809 | 0.65 | CREBBP (0.55) | GAAMAPTARBRD4CREBBP | |
| SCHEMBL2781001 | 0.65 | MAPT (0.55) | GAAMAPTARBRD4CREBBP | |
| SCHEMBL11207070 | 0.65 | MAPT (0.50) | GAAMAPTARBRD4CREBBP | |
| SCHEMBL6954505 | 0.65 | MAPT (0.50) | GAAMAPTARBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232313-B1 | TREATING STROKE OR EPILEPTIC CONVULSIONS ASSOCIATED WITH EXCESSIVE CALCIUM INFLUX IN THE BRAIN CAUSED BY EXCITATORY AMINO ACIDS | ZENECA LIMITED (GB) | 2001-05-15 | — | — | US | disclosed |
| US-6214826-B1 | NERVOUS SYSTEM DISORDERS | ZENECA LIMITED (GB) | 2001-04-10 | — | — | US | disclosed |