Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 11/20 | 0.69 |
| ▸ | GSK3B | P49841 | 10/20 | 0.69 |
| ▸ | PIM1 | P11309 | 10/20 | 0.69 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.69 |
| ▸ | CSNK1D | P48730 | 9/20 | 0.69 |
| ▸ | CDK2 | P24941 | 9/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.69 |
| ▸ | CHEK2 | O96017 | 8/20 | 0.69 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.69 |
| ▸ | CDK1 | P06493 | 8/20 | 0.69 |
| ▸ | CSNK2A1 | P68400 | 7/20 | 0.69 |
| ▸ | DAPK3 | O43293 | 7/20 | 0.69 |
| ▸ | PLK4 | O00444 | 7/20 | 0.69 |
| ▸ | AURKA | O14965 | 7/20 | 0.69 |
| ▸ | PLK3 | Q9H4B4 | 6/20 | 0.69 |
| ▸ | RPS6KA3 | P51812 | 6/20 | 0.69 |
| ▸ | PRKACA | P17612 | 6/20 | 0.69 |
| ▸ | SGK2 | Q9HBY8 | 6/20 | 0.69 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.69 |
| ▸ | MAP3K8 | P41279 | 5/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053722 | 0.88 | PIM1 (0.69) | GSK3AGSK3BPIM1DYRK1ACSNK1D | |
| SCHEMBL7797363 | 0.86 | GSK3A (0.77) | GSK3AGSK3BPIM1DYRK1ACSNK1D | |
| SCHEMBL7619323 | 0.82 | GSK3A (1.00) | GSK3AGSK3BPIM1DYRK1ACSNK1D | |
| SCHEMBL7934399 | 0.81 | GSK3A (0.78) | GSK3AGSK3BPIM1DYRK1ACSNK1D | |
| SCHEMBL5555935 | 0.80 | MAP3K8 (1.00) | GSK3AGSK3BPIM1DYRK1ACSNK1D | |
| SCHEMBL658705 | 0.78 | ICAM1 (0.73) | GSK3AGSK3BPIM1DYRK1ACSNK1D | |
| SCHEMBL7111799 | 0.78 | GSK3A (0.64) | GSK3AGSK3BPIM1DYRK1ACSNK1D | |
| SCHEMBL7250463 | 0.78 | MAP3K8 (0.77) | GSK3AGSK3BPIM1DYRK1ACSNK1D | |
| SCHEMBL7055360 | 0.75 | PIM1 (0.76) | GSK3AGSK3BPIM1DYRK1ACSNK1D | |
| SCHEMBL5550778 | 0.74 | PIM1 (0.78) | GSK3AGSK3BPIM1DYRK1ACSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232320-B1 | THIENO(2,3-C)PYRIDINE AND 5H-THIENO(2,3-C)PYRAN DERIATIVES | ABBOTT LABORATORIES | 2001-05-15 | — | — | US | disclosed |