Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.32 |
| ▸ | KDR | P35968 | 6/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | HCK | P08631 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13456554 | 0.85 | KDR (0.42) | CHRNA7S1PR1OXER1NR1H2KDR | |
| SCHEMBL8047542 | 0.72 | BRD4 (0.44) | CHRNA7S1PR1NR1H2KDRPIK3CD | |
| SCHEMBL3007425 | 0.72 | NR1H2 (0.45) | CHRNA7S1PR1HPGDALOX15NR1H2 | |
| SCHEMBL13428863 | 0.72 | PIK3CD (0.45) | CHRNA7S1PR1OXER1HPGDALOX15 | |
| SCHEMBL3047553 | 0.71 | PDCD1 (0.41) | CHRNA7S1PR1NR1H2KDRPIK3CD | |
| SCHEMBL1253366 | 0.70 | CHRNA7 (0.50) | CHRNA7 | |
| SCHEMBL12043978 | 0.69 | PIK3CD (0.44) | S1PR1OXER1NR1H2KDRPIK3CD | |
| SCHEMBL1057433 | 0.69 | PIK3CD (0.44) | S1PR1OXER1NR1H2KDRPIK3CD | |
| SCHEMBL29658586 | 0.69 | PIK3CD (0.44) | S1PR1OXER1NR1H2KDRPIK3CD | |
| SCHEMBL1058348 | 0.68 | PIK3CD (0.44) | S1PR1OXER1NR1H2KDRPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010030967-A1 | 4-ARYLOXYQUINOLIN-2(1H)-ONES AS MTOR KINASE AND PI3 KINASE INHIBITORS, FOR USE AS ANTI-CANCER AGENTS | WYETH LLC (US) | 2010-03-18 | — | — | WO | disclosed |