Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 7/20 | 0.69 |
| ▸ | CCR3 | P51677 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TACR2 | P21452 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7934611 | 0.90 | TACR1 (0.56) | TACR1CCR3HTTSIGMAR1THRB | |
| SCHEMBL7925929 | 0.83 | TACR1 (0.88) | TACR1CCR3 | |
| SCHEMBL7989837 | 0.81 | TACR1 (1.00) | TACR1CCR3 | |
| SCHEMBL7985915 | 0.73 | TACR1 (0.59) | TACR1CCR3 | |
| SCHEMBL7925934 | 0.73 | TACR1 (0.72) | TACR1CCR3 | |
| SCHEMBL7989839 | 0.71 | TACR1 (0.81) | TACR1CCR3 | |
| Hydrochloric Acid SCHEMBL6229648 | 0.71 | TACR1 (0.52) | TACR1CCR3TACR2 | |
| Hydrochloric Acid SCHEMBL8432074 | 0.69 | TACR1 (0.52) | TACR1TACR2CNR2 | |
| Hydrochloric Acid SCHEMBL8067085 | 0.69 | TACR1 (0.48) | TACR1TACR2 | |
| SCHEMBL7926232 | 0.67 | TACR1 (1.00) | TACR1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191135-B1 | Neurokinin antagonists | BOEHRINGER INGELHEIM KG (DE) | 2001-02-20 | — | — | US | claimed |
| US-6235732-B1 | RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; SKIN DISORDERS | BOEHRINGER INGELHEIM KG (DE) | 2001-05-22 | — | — | US | disclosed |
| US-6191135-B1 | Neurokinin antagonists | BOEHRINGER INGELHEIM KG (DE) | 2001-02-20 | — | — | US | disclosed |
| US-5985881-A | TREATMENT AND PREVENTION OF RESPIRATORY DISORDERS, INFLAMMATORY EYE DISEASES, INFLAMMATORY SKIN DISEASES, INTESTINAL DISORDERS, OTHER INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM KG (DE) | 1999-11-16 | — | — | US | disclosed |
| WO-1996008480-A1 | NEUROKININ ANTAGONISTS | BOEHRINGER INGELHEIM KG (DE) | 1996-03-21 | — | — | WO | disclosed |