Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7933404 | 0.94 | BACE1 (0.87) | BACE1 | |
| SCHEMBL7941209 | 0.94 | BACE1 (0.87) | BACE1 | |
| SCHEMBL7942230 | 0.93 | BACE1 (0.85) | BACE1 | |
| SCHEMBL7945608 | 0.93 | BACE1 (1.00) | BACE1 | |
| SCHEMBL12302136 | 0.92 | BACE1 (0.83) | BACE1 | |
| SCHEMBL7944195 | 0.91 | BACE1 (1.00) | BACE1 | |
| SCHEMBL7941205 | 0.90 | BACE1 (0.84) | BACE1 | |
| SCHEMBL7941208 | 0.89 | BACE1 (0.88) | BACE1 | |
| SCHEMBL7941213 | 0.88 | BACE1 (0.86) | BACE1 | |
| SCHEMBL7939450 | 0.88 | BACE1 (0.67) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |