Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.60 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.53 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.49 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.49 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.49 |
| ▸ | RICTOR | Q6R327 | 5/20 | 0.49 |
| ▸ | MAPKAP1 | Q9BPZ7 | 5/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL413932 | 0.86 | MTOR (0.54) | MTORPIK3R1PIK3CDPIK3CARPTOR | |
| SCHEMBL443148 | 0.86 | MTOR (0.54) | MTORPIK3R1PIK3CDPIK3CARPTOR | |
| SCHEMBL443968 | 0.83 | MTOR (0.58) | MTORPIK3R1PIK3CDPIK3CARPTOR | |
| SCHEMBL2708323 | 0.83 | MTOR (0.55) | MTORPIK3R1PIK3CDPIK3CARPTOR | |
| SCHEMBL2708328 | 0.83 | MTOR (0.55) | MTORPIK3R1PIK3CDPIK3CARPTOR | |
| SCHEMBL15196028 | 0.82 | MTOR (0.51) | MTORPIK3R1PIK3CDPIK3CARPTOR | |
| SCHEMBL1831431 | 0.82 | MTOR (0.88) | MTORPIK3CARPTORMLST8CYP3A4 | |
| SCHEMBL441373 | 0.82 | MTOR (0.88) | MTORPIK3CARPTORMLST8CYP3A4 | |
| SCHEMBL441374 | 0.82 | MTOR (0.88) | MTORPIK3CARPTORMLST8CYP3A4 | |
| SCHEMBL1833942 | 0.81 | MTOR (0.67) | MTORPIK3R1PIK3CDPIK3C2ABRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010014939-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-02-04 | — | — | WO | disclosed |