Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.30 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2404373 | 0.79 | HDAC6 (0.51) | HDAC8HDAC6HDAC3HDAC1HDAC4 | |
| SCHEMBL2404370 | 0.79 | HDAC6 (0.51) | HDAC8HDAC6HDAC3HDAC1HDAC4 | |
| SCHEMBL2404311 | 0.78 | HDAC6 (0.61) | HDAC8HDAC6HDAC3HDAC1HDAC4 | |
| SCHEMBL2404315 | 0.78 | HDAC6 (0.61) | HDAC8HDAC6HDAC3HDAC1HDAC4 | |
| SCHEMBL2406196 | 0.77 | HDAC6 (0.47) | HDAC8HDAC6HDAC3HDAC1HDAC4 | |
| SCHEMBL2406201 | 0.72 | HDAC6 (0.43) | HDAC8HDAC6HDAC3HDAC1HDAC4 | |
| SCHEMBL2406199 | 0.72 | HDAC6 (0.43) | HDAC8HDAC6HDAC3HDAC1HDAC4 | |
| SCHEMBL2404723 | 0.70 | HDAC1 (0.48) | HDAC8HDAC6HDAC3HDAC1HDAC4 | |
| SCHEMBL2404726 | 0.70 | HDAC1 (0.48) | HDAC8HDAC6HDAC3HDAC1HDAC4 | |
| SCHEMBL2405764 | 0.64 | HDAC6 (0.65) | HDAC8HDAC6HDAC3HDAC1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043953-A2 | NOVEL BRIDGED CYCLIC COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2010-04-22 | — | — | WO | disclosed |