Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 20/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7934063 | 0.90 | PDE10A (0.90) | PDE10A | |
| SCHEMBL1303633 | 0.90 | PDE10A (0.90) | PDE10A | |
| SCHEMBL1303205 | 0.90 | PDE10A (0.90) | PDE10A | |
| SCHEMBL7940560 | 0.90 | PDE10A (0.79) | PDE10A | |
| SCHEMBL3350551 | 0.89 | PDE10A (0.78) | PDE10A | |
| SCHEMBL1302351 | 0.89 | PDE10A (1.00) | PDE10A | |
| SCHEMBL1304725 | 0.88 | PDE10A (1.00) | PDE10A | |
| SCHEMBL1303770 | 0.88 | PDE10A (0.77) | PDE10A | |
| SCHEMBL1303765 | 0.88 | PDE10A (0.77) | PDE10A | |
| SCHEMBL1304209 | 0.88 | PDE10A (0.77) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364308-B1 | PYRAZINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2010057121-A1 | PYRAZINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2010-05-20 | — | — | WO | disclosed |