Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | GLP1R | P43220 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052776 | 0.79 | KDM4E (0.44) | KDM4EKMT2ACYP1A2TYMSNPC1 | |
| SCHEMBL2023290 | 0.79 | KDM4E (0.44) | KDM4EKMT2ACYP1A2TYMSNPC1 | |
| SCHEMBL7937979 | 0.76 | KDM4E (0.53) | KDM4EKMT2ABACE1DYRK1ACYP1A2 | |
| SCHEMBL12638660 | 0.76 | KDM4E (0.53) | KDM4EKMT2ABACE1DYRK1ACYP1A2 | |
| SCHEMBL2021348 | 0.75 | NPC1 (0.43) | KDM4EKMT2ANPC1MAPTRAB9A | |
| SCHEMBL18684816 | 0.73 | KDM4E (0.42) | KDM4EKMT2ABACE1CYP1A2NPC1 | |
| SCHEMBL789176 | 0.72 | KDM4E (0.41) | KDM4EKMT2ABACE1CYP1A2NPC1 | |
| SCHEMBL789356 | 0.72 | KDM4E (0.41) | KDM4EKMT2ABACE1CYP1A2NPC1 | |
| SCHEMBL6177668 | 0.71 | TYR (0.44) | KDM4EKMT2ANPC1MAPTRAB9A | |
| SCHEMBL22369961 | 0.70 | KDM4E (0.39) | KDM4EKMT2ACYP1A2NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010027097-A1 | TRI-SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-03-11 | — | — | WO | disclosed |