⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15301 | 1.00 | — | — | |
| SCHEMBL2000099 | 1.00 | — | — | |
| SCHEMBL3515 | 0.74 | — | — | |
| SCHEMBL585568 | 0.73 | — | — | |
| SCHEMBL9206748 | 0.73 | — | — | |
| SCHEMBL9246953 | 0.73 | — | — | |
| SCHEMBL5661656 | 0.71 | — | — | |
| SCHEMBL29676 | 0.70 | — | — | |
| SCHEMBL5985870 | 0.70 | — | — | |
| SCHEMBL20636755 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791132-A1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | Seragon Pharmaceuticals, Inc. (US) | 2014-10-22 | — | — | EP | disclosed |
| EP-2616445-A2 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | Aragon Pharmaceuticals, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2013090829-A1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ARAGON PHARMACEUTICALS, INC. (US) | 2013-06-20 | — | — | WO | disclosed |
| EP-1763522-B1 | PYRIDIN-2-ONE COMPOUNDS AND THEIR USE AS MODULATORS OF THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO KG (DE) | 2013-03-20 | — | — | EP | disclosed |
| US-8334289-B2 | Pyridin-2-one compounds and their use as modulators of the dopamine D3 receptor | ABBOTT GMBH & CO. KG (DE) | 2012-12-18 | — | — | US | disclosed |
| WO-2012037411-A9 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ARAGON PHARMACEUTICALS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |
| WO-2012037411-A2 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ARAGON PHARMACEUTICALS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |
| US-20110245266-A1 | PYRIDIN-2-ONE COMPOUNDS AND THEIR USE AS MODULATORS OF THE DOPAMINE D3 RECEPTOR | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2011-10-06 | — | — | US | disclosed |
| US-7960386-B2 | 1-(4-{4-[2-tert-Butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl}butyl)-4-methylpyridin-2(1H)-one; treatment of schizophrenia and/or depression | ABBOTT GMBH & CO. KG (DE) | 2011-06-14 | — | — | US | disclosed |
| US-20080261992-A1 | Pyridin-2-One Compounds and Their Use as Modulators of the Dopamine D3 Receptor | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2008-10-23 | — | — | US | disclosed |
| EP-1763522-A1 | PYRIDIN-2-ONE COMPOUNDS AND THEIR USE AS MODULATORS OF THE DOPAMINE D3 RECEPTOR | Abbott GmbH & Co. KG (DE) | 2007-03-21 | — | — | EP | disclosed |
| WO-2005118571-A1 | PYRIDIN-2-ONE COMPOUNDS AND THEIR USE AS MODULATORS OF THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO. KG (DE) | 2005-12-15 | — | — | WO | disclosed |
| US-5534171-A | REACTION PRODUCT OF ETHYLENE COPOLYMER, MALEIC ANHYDRIDE, AND AMINO THIADIAZOLE | DSM COPOLYMER INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5472627-A | Oil additive comprising an ethylene/alpha-olefin copolymer grafted with unsaturated acid and subsequently modified by a 2-amino-1,3,4-thiadiazole | TEXACO INC. (US) | 1995-12-05 | — | — | US | disclosed |