Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | VHL | P40337 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1320408 | 0.77 | VHL (0.41) | EPHX2PDE10AVHLNPC1RAB9A | |
| SCHEMBL1320181 | 0.74 | VHL (0.41) | EPHX2PDE10AVHLALDH1A1S1PR1 | |
| SCHEMBL6409949 | 0.73 | EPHX2 (0.57) | EPHX2ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2258741 | 0.73 | VHL (0.44) | EPHX2PDE10AVHLALDH1A1SMN1; SMN2 | |
| SCHEMBL7992354 | 0.72 | VHL (0.44) | EPHX2PDE10AVHLALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4305870 | 0.72 | VHL (0.42) | EPHX2PDE10AVHLALDH1A1SMN1; SMN2 | |
| SCHEMBL1320569 | 0.71 | S1PR1 (0.40) | EPHX2PDE10AVHLALDH1A1NPC1 | |
| SCHEMBL14947414 | 0.70 | POLB (0.47) | EPHX2PDE10AVHLALDH1A1SMN1; SMN2 | |
| SCHEMBL16232505 | 0.70 | VHL (0.42) | EPHX2VHLALDH1A1NPC1RAB9A | |
| SCHEMBL14364098 | 0.70 | NPC1 (0.49) | VHLALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |