SCHEMBL7939394

SCHEMBL7939394

C=CCCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@]1(C(=O)O)C[C@H]1C=C

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 4/20 0.40
HDAC8 Q9BY41 4/20 0.40
HDAC4 P56524 1/20 0.39
CYP3A4 P08684 1/20 0.38
ITGB3 P05106 7/20 0.36
ITGA2B P08514 7/20 0.36
CTSB P07858 1/20 0.34
PPP3CB P16298 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8267377 0.93 HDAC1 (0.40) HDAC1HDAC8HDAC4CYP3A4ITGB3
SCHEMBL13711157 0.93 HDAC1 (0.40) HDAC1HDAC8HDAC4CYP3A4ITGB3
SCHEMBL3674630 0.91 HDAC1 (0.39) HDAC1HDAC8HDAC4CYP3A4ITGB3
SCHEMBL17676680 0.91 HDAC1 (0.39) HDAC1HDAC8HDAC4CYP3A4ITGB3
SCHEMBL8026867 0.91 HDAC1 (0.39) HDAC1HDAC8HDAC4CYP3A4ITGB3
SCHEMBL1943013 0.91 HDAC1 (0.39) HDAC1HDAC8HDAC4CYP3A4ITGB3
SCHEMBL13783718 0.91 HDAC1 (0.39) HDAC1HDAC8HDAC4CYP3A4ITGB3
SCHEMBL10254350 0.91 HDAC1 (0.39) HDAC1HDAC8HDAC4CYP3A4ITGB3
SCHEMBL15747003 0.91 HDAC1 (0.39) HDAC1HDAC8HDAC4CYP3A4ITGB3
SCHEMBL330255 0.91 HDAC1 (0.39) HDAC1HDAC8HDAC4CYP3A4ITGB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2225249-B1 PROCESS FOR THE PREPARATION OF A MACROCYCLE HOFFMANN LA ROCHE (CH) 2016-08-03 EP disclosed
EP-2323981-B1 PROCESS FOR THE PREPARATION OF A MACROCYCLE HOFFMANN LA ROCHE (CH) 2014-03-12 EP disclosed
WO-2010015545-A1 PROCESS FOR THE PREPARATION OF A MACROCYCLE F. HOFFMANN-LA ROCHE AG (CH) 2010-02-11 WO disclosed
WO-2009124853-A1 NEW RUTHENIUM COMPLEXES AS CATALYSTS FOR METATHESIS REACTIONS F. HOFFMANN-LA ROCHE AG (CH) 2009-10-15 WO disclosed
WO-2009080542-A1 PROCESS FOR THE PREPARATION OF A MACROCYCLE F. HOFFMANN-LA ROCHE AG (CH) 2009-07-02 WO disclosed