Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 13/20 | 0.51 |
| ▸ | EDNRB | P24530 | 12/20 | 0.51 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314152 | 0.84 | EDNRA (0.66) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL7946892 | 0.80 | EDNRA (0.49) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL7951402 | 0.79 | EDNRA (0.46) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL6313203 | 0.78 | EDNRA (0.63) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL7949184 | 0.78 | EDNRA (0.50) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL7252032 | 0.73 | EDNRA (0.68) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL6313421 | 0.72 | EDNRA (0.66) | EDNRAEDNRBHSD17B10ALDH1A1KDM4E | |
| SCHEMBL6313378 | 0.69 | EDNRA (0.63) | EDNRAEDNRBHSD17B10KDM4ERAB9A | |
| SCHEMBL7046426 | 0.67 | MEN1 (0.61) | EDNRAHSD17B10ALDH1A1KDM4ERAB9A | |
| SCHEMBL4631351 | 0.67 | EDNRB (1.00) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |