Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.34 |
| ▸ | APP | P05067 | 7/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12565340 | 0.85 | BACE1 (0.48) | BACE1APPCTSDMAPTBACE2 | |
| SCHEMBL1992787 | 0.85 | BACE1 (0.48) | BACE1 | |
| SCHEMBL1996400 | 0.81 | BACE1 (0.42) | BACE1APPCTSD | |
| SCHEMBL1996985 | 0.80 | BACE1 (0.56) | BACE1APPCTSDNPC1MAPT | |
| SCHEMBL1992797 | 0.80 | BACE1 (0.38) | BACE1CTSDNPC1MAPTRAB9A | |
| SCHEMBL1990774 | 0.77 | KDM1A (0.42) | BACE1APPCTSDBACE2 | |
| SCHEMBL7940629 | 0.77 | BACE1 (0.51) | BACE1APPCTSDMAPTBACE2 | |
| SCHEMBL1995980 | 0.75 | BACE1 (0.46) | BACE1APPCTSDBACE2 | |
| SCHEMBL1991931 | 0.75 | BACE1 (0.53) | BACE1CTSD | |
| SCHEMBL7941101 | 0.75 | BACE1 (0.46) | BACE1APPBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010013794-A1 | SPIROAMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-02-04 | — | — | WO | disclosed |