Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 20/20 | 0.64 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL793283 | 0.84 | ELANE (0.55) | ELANEF2PLAU | |
| SCHEMBL9959858 | 0.84 | ELANE (0.57) | ELANEF2PLAU | |
| SCHEMBL24247769 | 0.82 | ELANE (0.55) | ELANEF2PLAU | |
| SCHEMBL19149065 | 0.80 | ELANE (0.53) | ELANEF2PLAU | |
| SCHEMBL19127407 | 0.78 | ELANE (0.51) | ELANEF2PLAU | |
| SCHEMBL491986 | 0.78 | ELANE (0.48) | ELANEF2PLAU | |
| SCHEMBL793288 | 0.78 | PDGFRA (0.54) | ELANEPLAU | |
| SCHEMBL13502780 | 0.77 | KDM4E (0.55) | ELANE | |
| SCHEMBL492581 | 0.77 | ELANE (0.47) | ELANEF2PLAU | |
| SCHEMBL20740648 | 0.77 | PDGFRA (0.50) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616443-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | Exelixis, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012037132-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |