Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.55 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3118213 | 0.94 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4CCTSD | |
| SCHEMBL3122409 | 0.85 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4CCTSD | |
| SCHEMBL3126047 | 0.85 | PDE4A (0.48) | PDE4APDE4DPDE4BPDE4CCTSD | |
| SCHEMBL3131197 | 0.83 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4CCTSD | |
| SCHEMBL7940974 | 0.83 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4CCTSD | |
| SCHEMBL3123727 | 0.83 | PDE4A (0.46) | PDE4APDE4DPDE4BPDE4CCTSD | |
| SCHEMBL3131352 | 0.82 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1157704 | 0.81 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4CGRM2 | |
| SCHEMBL3128964 | 0.81 | PDE4A (0.50) | PDE4APDE4DPDE4BPDE4CCTSD | |
| SCHEMBL1157078 | 0.80 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4CGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |