Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21212290 | 0.79 | UHRF1 (0.40) | CHRNA7UHRF1CYP17A1PDK2PDK4 | |
| SCHEMBL28115039 | 0.76 | TLR9 (0.42) | CHRNA7UHRF1CYP17A1PDK2PDK4 | |
| SCHEMBL18017351 | 0.75 | UHRF1 (0.45) | CHRNA7UHRF1CYP17A1PDK2PDK4 | |
| SCHEMBL20733724 | 0.73 | CHRNA7 (0.40) | CHRNA7UHRF1CYP17A1PDK2PDK4 | |
| SCHEMBL19225568 | 0.72 | CHRNA7 (0.39) | CHRNA7UHRF1CYP17A1PDK2PDK4 | |
| SCHEMBL25930436 | 0.72 | UHRF1 (0.47) | CHRNA7UHRF1CYP17A1PDK2PDK4 | |
| SCHEMBL12305125 | 0.71 | PSMB5 (0.41) | CHRNA7UHRF1TLR9TLR8TLR7 | |
| SCHEMBL25792497 | 0.69 | CNR2 (0.39) | CHRNA7CYP17A1TLR8TLR7CNR2 | |
| SCHEMBL20844157 | 0.69 | — | — | |
| SCHEMBL21616762 | 0.68 | PDCD1 (0.34) | CHRNA7CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010054278-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2010-05-14 | — | — | WO | disclosed |