Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 15/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359362 | 0.88 | BACE1 (0.54) | BACE1KCNH2BACE2 | |
| SCHEMBL3359201 | 0.83 | BACE1 (0.44) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL3360850 | 0.80 | BACE1 (0.38) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL3357760 | 0.78 | BACE1 (0.53) | BACE1KCNH2BACE2 | |
| SCHEMBL3357857 | 0.77 | BACE1 (0.62) | BACE1KCNH2BACE2 | |
| SCHEMBL3358115 | 0.77 | BACE1 (0.58) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL3360047 | 0.73 | BACE1 (0.42) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL3358036 | 0.73 | BACE1 (0.68) | BACE1KCNH2BACE2 | |
| SCHEMBL3360616 | 0.72 | BACE1 (0.49) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL3245127 | 0.70 | BACE1 (0.39) | BACE1KCNH2BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056194-A1 | 5H-PYRROLO [ 3, 4-B] PYRIDIN DERIVATIVES AND THEIR USE | ASTRAZENECA AB (SE) | 2010-05-20 | — | — | WO | disclosed |