Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.60 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7942878 | 0.89 | BACE1 (0.75) | BACE1BACE2APP | |
| SCHEMBL12301454 | 0.89 | BACE1 (0.51) | BACE1BACE2AURKAAURKB | |
| SCHEMBL7944850 | 0.88 | BACE1 (0.56) | BACE1BACE2AURKAAURKB | |
| SCHEMBL7943122 | 0.87 | BACE1 (0.58) | BACE1BACE2AURKAAURKB | |
| SCHEMBL7945065 | 0.87 | BACE1 (0.53) | BACE1BACE2AURKAAURKB | |
| SCHEMBL7944561 | 0.86 | BACE1 (0.49) | BACE1BACE2AURKAAURKB | |
| SCHEMBL7940351 | 0.86 | BACE1 (0.80) | BACE1BACE2APPAURKAAURKB | |
| SCHEMBL7942895 | 0.86 | BACE1 (0.62) | BACE1BACE2APP | |
| SCHEMBL7935468 | 0.85 | BACE1 (0.48) | BACE1BACE2AURKAAURKB | |
| SCHEMBL7941722 | 0.85 | BACE1 (0.51) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |